ABSTRACT
Objective@#To study the polymorphism in P66 and its human B-cell epitopes of @*Methods@#Polymerase chain reaction (PCR) and sequencing were used to obtain the P66 sequences of 59 Chinese @*Results@#Results showed that genetic and amino acid diversity presented in the 66 kD protein of all 59 Chinese strains, especially in @*Conclusion@#In P66 of 59 Chinese strains, polymorphisms were widely distributed. More importantly, the P66 amino acid sequences of
Subject(s)
Humans , Bacterial Proteins/genetics , Borrelia burgdorferi/genetics , China , Cluster Analysis , Epitopes, B-Lymphocyte/genetics , Genetic Markers , Genotype , Mutation , Polymerase Chain Reaction , Polymorphism, Genetic , Porins/geneticsABSTRACT
<p><b>OBJECTIVE</b>To compare the complete remission rate (CRR) and adverse reaction of the 3 different chemotherapy regimens (daunorubicin, idarubicin, imported idarubicin combined with cytarabine) for the treatment of adult patients with newly diagnosed non-M3 acute myeloid leukemia (AML).</p><p><b>METHODS</b>Seventy-one adult patients with newly diagnosed non-M3 AML were divided into 3 groups: 17 cases treated with daunorubicin plus cytarabine as group A, 24 cases treated with idarubicin plus cytarabine as group B, 30 cases treated with the imported idarubicin plus cytarabine as group C. The curative effects and adverse reactions were compared among the 3 groups after treatment.</p><p><b>RESULTS</b>CCR in group C (86.67%) was significantly higher than that in group A (52.94%) and group B (70.83%), and the CRR in group B was significantly higher than that in group A (P<0.05). The incidence of adverse reaction such as nausea, vomiting, myelosuppression and infection among 3 groups were not statistically significantant (P>0.05).</p><p><b>CONCLUSION</b>The curative effect of idarubicin for the treatment of non-M3 AML patients is better than that of daunorubicin, especially the curative efficiency of imported darubicin is much higher; the adverse reaction after treatment by daunorubicin and idarubicin can be controllable, so daunorubicin and idarubicin can be used as first-line drug for the patients with AML, and patients can choose more appropriate drug according to their own economic ability.</p>
Subject(s)
Adult , Humans , Antineoplastic Combined Chemotherapy Protocols , Cytarabine , Daunorubicin , Idarubicin , Leukemia, Myeloid, Acute , Remission InductionABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of Penqiangyan Granule (PG) on the immunity of patients with chronic pelvic inflammatory disease (CPID) of blood stasis and Shen-deficiency syndrome (BSSDS) type.</p><p><b>METHODS</b>Sixty patients were randomly assigned to two groups: the treatment group treated with PG and the control group with Penyanjing Granule, 30 cases in each group. The treatment course was 4 weeks for both groups. The clinical efficacy, plasma levels of CD4 and CD8, and the serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2) were measured before and after treatment.</p><p><b>RESULTS</b>After treatment, the total effective rate in the treatment group and the control group was 96.7% and 63.3% respectively with significant difference between groups (P < 0.05); in the treatment group the plasma CD4, CD4/CD8 and serum IL-2 increased obviously, while the plasma CD8 and serum TNF-alpha decreased markedly (P < 0.05), all were significantly different with those in the control group (P < 0.05).</p><p><b>CONCLUSION</b>PG can improve the immune function and alleviate inflammation in CPID patients of BSSDS type.</p>
Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , CD4-CD8 Ratio , Chronic Disease , Diagnosis, Differential , Drugs, Chinese Herbal , Therapeutic Uses , Interleukin-2 , Blood , Medicine, Chinese Traditional , Pelvic Inflammatory Disease , Diagnosis , Drug Therapy , Allergy and Immunology , Phytotherapy , Syndrome , Treatment Outcome , Tumor Necrosis Factor-alpha , Blood , Yang Deficiency , Diagnosis , Drug Therapy , Allergy and ImmunologyABSTRACT
@#ObjectiveTo explore the characteristics of phonological encoding of Chinese disyllabic compound words in patients with mild cognition impairment(MCI). Methods10 patients with MCI and 10 normal controls who matched with the age, gender, level of education and handedness performed homophone judgment task. In this task, a picture with a disyllabic compound name was presented, after 100 ms of the presentation there would be a Chinese character below the picture. Subjects were asked to judge whether one of the morpheme in the picture name was homophonic to the character. The reaction time and error ratio were analyzed statistically. ResultsIn the normal controls, the reaction time for the second constituents was shorter than that for the first constituents, while there were no difference between the first and second constituents reaction time in MCI patients. The error ratio of the first and second constituents showed no difference in normal controls, but MCI patients made more error rate for the first constituents. ConclusionAs the heathy elderly,the MCI patients have same pattern in phonological coding of Chinese disyllabic compound words, but much slower in activation speed, indicating the impairment of semantic memory and phonological activation in patients with MCI.